Structure of PDB 4khu Chain A Binding Site BS01

Receptor Information
>4khu Chain A (length=898) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVIESREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLK
YDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKIQ
IQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRY
KYVMSFDLTSFYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVY
SCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEALH
NPNLSVDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMT
AQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEY
LNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKF
ARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTG
KKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQ
EGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFH
IRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEI
TDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASLFDMFD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4khu Structure-function analysis of ribonucleotide bypass by B family DNA replicases.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		S360 P361 I362 Y391 P392 G393 A394 S565 Y567 G568 N572 W574 K705 K706 R707 K800 K844 K874
Binding residue
(residue number reindexed from 1)		S356 P357 I358 Y387 P388 G389 A390 S561 Y563 G564 N568 W570 K701 K702 R703 K796 K840 K870
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4khu, PDBe:4khu, PDBj:4khu
PDBsum4khu
PubMed24082122
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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