Structure of PDB 4khs Chain A Binding Site BS01

Receptor Information
>4khs Chain A (length=893) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
REIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLKYDGPI
SKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKIQIQSVF
SPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRYKYVMS
FDLTSFYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVYSCSPN
GMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEALHNPNLS
VDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMTAQINR
KLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEYLNEVC
GTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKFARERM
EPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTGKKRYA
LNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQEGEES
LQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFHIRGIL
TYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEITDLIK
DDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASLFDMFD
Ligand information
Receptor-Ligand Complex Structure
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PDB4khs Structure-function analysis of ribonucleotide bypass by B family DNA replicases.
Resolution2.12 Å
Binding residue
(original residue number in PDB)		N284 D621 M728 G729 K734 S735 S783 S784 N786 Y791 H804
Binding residue
(residue number reindexed from 1)		N275 D612 M719 G720 K725 S726 S774 S775 N777 Y782 H795
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4khs, PDBe:4khs, PDBj:4khs
PDBsum4khs
PubMed24082122
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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