Structure of PDB 4k97 Chain A Binding Site BS01
Receptor Information
>4k97 Chain A (length=351) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKPLSHFLEG
EVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEI
SVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKD
GNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYL
LEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLA
FFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIF
D
Ligand information
>4k97 Chain D (length=15) [
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aaattgccgaagacg
Receptor-Ligand Complex Structure
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PDB
4k97
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Resolution
2.41 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 R180 H203 N376 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 R32 H55 N222 K241
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4k97
,
PDBe:4k97
,
PDBj:4k97
PDBsum
4k97
PubMed
23647843
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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