Structure of PDB 4k8y Chain A Binding Site BS01

Receptor Information
>4k8y Chain A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIG
LGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESD
TIRSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSK
LYDPLYHPSMFCAGGGQDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQ
VGVPGVYTNLCKFTEWIEKTVQA
Ligand information
Receptor-Ligand Complex Structure
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PDB4k8y Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics
Resolution1.0 Å
Binding residue
(original residue number in PDB)		F41 H57 L99 S190 C191 N192 G193 S195 S214 F215 G216 K217
Binding residue
(residue number reindexed from 1)		F25 H41 L83 S172 C173 N174 G175 S177 S192 F193 G194 K195
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 N192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D86 N174 G175 D176 S177 G178
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0031214 biomineral tissue development
GO:0097186 amelogenesis
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4k8y, PDBe:4k8y, PDBj:4k8y
PDBsum4k8y
PubMed27767076
UniProtQ9Y5K2|KLK4_HUMAN Kallikrein-4 (Gene Name=KLK4)

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