Structure of PDB 4k6n Chain A Binding Site BS01

Receptor Information
>4k6n Chain A (length=352) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNFEVLATFRYDPGFARQSASKKEIFETPDPRLGLRDEDIRQQIINEDYS
SYLRVREVNSGGDLLENIQHPDAWKHDCKTIVCQRVEDMLQVIYERFFLL
DEQYQRIRIALSYFKIDFSTSLNDLLKLLVENLINCKEGNSEYHEKIQKM
INERQCYKMRVLVSKTGDIRIEAIPMPMEPILKLTTDYDSVSTYFIKTML
NGFLIDSTINWDVVVSSEPLNASAFTSFKTTSRDHYARARVRMQTAINNL
RGSEPTSSVSQCEILFSNKSGLLMEGSITNVAVIQKDPNGSKKYVTPRLA
TGCLCGTMRHYLLRLGLIEEGDIDIGSLTVGNEVLLFNGVMGCIKGTVKT
KY
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain4k6n Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4k6n Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase
Resolution1.9 Å
Binding residue
(original residue number in PDB)		R128 K251 R255 Y258 E297 S299 T301 N302 L326 G328 T329 M330 N360 G361
Binding residue
(residue number reindexed from 1)		R106 K229 R233 Y236 E275 S277 T279 N280 L304 G306 T307 M308 N338 G339
Annotation score1
Enzymatic activity
Enzyme Commision number 4.1.3.38: aminodeoxychorismate lyase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008696 4-amino-4-deoxychorismate lyase activity
GO:0016829 lyase activity
Biological Process
GO:0019752 carboxylic acid metabolic process
GO:0046394 carboxylic acid biosynthetic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4k6n, PDBe:4k6n, PDBj:4k6n
PDBsum4k6n
PubMed23818518
UniProtQ03266|PABC_YEAST Aminodeoxychorismate lyase (Gene Name=ABZ2)

[Back to BioLiP]