Structure of PDB 4k3m Chain A Binding Site BS01

Receptor Information
>4k3m Chain A (length=358) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFTVEREHLLKPLQQVSGLPILGNLLLQVADGTLSLTGTDLEMEMVARV
ALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFS
LSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNG
MLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRML
DGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLE
AGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILD
VTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSA
AYVVMPMR
Ligand information
Receptor-Ligand Complex Structure
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PDB4k3m Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp
Resolution1.85 Å
Binding residue
(original residue number in PDB)		R152 T172 G174 H175 R176 P242 V247 M362
Binding residue
(residue number reindexed from 1)		R145 T165 G167 H168 R169 P235 V240 M355
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032297 negative regulation of DNA-templated DNA replication initiation
GO:0042276 error-prone translesion synthesis
GO:0044787 bacterial-type DNA replication
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009360 DNA polymerase III complex
GO:0030894 replisome
GO:1990078 replication inhibiting complex
GO:1990085 Hda-beta clamp complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4k3m, PDBe:4k3m, PDBj:4k3m
PDBsum4k3m
PubMed24090409
UniProtP0A988|DPO3B_ECOLI Beta sliding clamp (Gene Name=dnaN)

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