Structure of PDB 4jrq Chain A Binding Site BS01

Receptor Information
>4jrq Chain A (length=460) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDY
LPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRF
DDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPEN
DDGLPSFRLEHLTKANGIHDAMADVYATIAMAKLVKTRQPRLFDYLFTHR
NKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRNAVIMV
DLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCPVLAQA
NTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEATPSDNVDA
QLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNF
PGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKVALLK
ALWQYAEEIV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4jrq Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D15 E17 T18 T21 A63 T67 Y102 N103 F107 R113 Y124 W128 R142 F164 R165 K214 M235 G237 A238 N255 Y284 T285 A286 K287 N304 E353 Y368 F371
Binding residue
(residue number reindexed from 1)		D8 E10 T11 T14 A56 T60 Y95 N96 F100 R106 Y117 W121 R135 F157 R158 K202 M223 G225 A226 N243 Y272 T273 A274 K275 N292 E341 Y353 F356
Enzymatic activity
Enzyme Commision number 3.1.11.1: exodeoxyribonuclease I.
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006274 DNA replication termination
GO:0006281 DNA repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4jrq, PDBe:4jrq, PDBj:4jrq
PDBsum4jrq
PubMed23609540
UniProtP04995|EX1_ECOLI Exodeoxyribonuclease I (Gene Name=sbcB)

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