Structure of PDB 4jlz Chain A Binding Site BS01

Receptor Information
>4jlz Chain A (length=363) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAWKLQTVLEKVRLSRHEISEAAEVVNWVVEHLLRRLQGGESEFKGVALL
RTGSYYERVKISAPNEFDVMFKLEVPRIQLEEYCNSGAHYFVKFKRNPGG
NPLEQFLEKEILSASKMLSKFRKIIKEEIKNIEDTGVTVERKRRGSPAVT
LLISKPKEISVDIILALESKSSWPASTQKGLPISQWLGAKVKNNLKRQPF
YLVPKHAKEGSGFQEETWRLSFSHIEKDILKNHGQSKTCCEIDGVKCCRK
ECLKLMKYLLEQLKKKFGNRRELAKFCSYHVKTAFFHVCTQDPHDNQWHL
KNLECCFDNCVAYFLQCLKTEQLANYFIPGVNLFSRDLIDKPSKEFLSKQ
IEYERNNGFPVFW
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4jlz Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4jlz Structural mechanism of cytosolic DNA sensing by cGAS
Resolution2.27 Å
Binding residue
(original residue number in PDB)		H367 C373 C374 C381
Binding residue
(residue number reindexed from 1)		H233 C239 C240 C247
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
External links
PDB RCSB:4jlz, PDBe:4jlz, PDBj:4jlz
PDBsum4jlz
PubMed23722159
UniProtI3LM39|CGAS_PIG Cyclic GMP-AMP synthase (Gene Name=CGAS)

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