Structure of PDB 4jlu Chain A Binding Site BS01

Receptor Information

>4jlu Chain A (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE
RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQG
PKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF
TLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQ
ELDTYLIPQIP

Ligand information

>4jlu Chain B (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GFGEYSRSPTF

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4jlu Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas
Resolution	3.5 Å
Binding residue (original residue number in PDB)	S1655 G1656 T1691 R1699 T1700 L1701
Binding residue (residue number reindexed from 1)	S7 G8 T43 R51 T52 L53

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006281	DNA repair
GO:0006974	DNA damage response

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:4jlu, PDBe:4jlu, PDBj:4jlu
PDBsum	4jlu
PubMed
UniProt	P38398\|BRCA1_HUMAN Breast cancer type 1 susceptibility protein (Gene Name=BRCA1)

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