Structure of PDB 4jlq Chain A Binding Site BS01

Receptor Information
>4jlq Chain A (length=840) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFV
LTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSS
PLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQ
KICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFII
SRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPH
MHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPV
LVNGMKYSDIDIILLKGDTISDWNLRKCSAAALDVLANVYRDELLPHILP
LLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDK
KALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAA
CSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLAD
SVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSG
FLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSG
LAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQ
HVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMV
LHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTS
LRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLR
DMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
Ligand information
>4jlq Chain B (length=7) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TRFNPLA
Receptor-Ligand Complex Structure
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PDB4jlq Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		K377 A380 W460 S502 A505 E509 D543
Binding residue
(residue number reindexed from 1)		K327 A330 W410 S452 A455 E459 D493
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005929 cilium
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jlq, PDBe:4jlq, PDBj:4jlq
PDBsum4jlq
PubMed23535894
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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