Structure of PDB 4jfn Chain A Binding Site BS01

Receptor Information
>4jfn Chain A (length=101) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQY
CQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEF
V
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain4jfn Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4jfn Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain
Resolution1.75 Å
Binding residue
(original residue number in PDB)		H108 H110
Binding residue
(residue number reindexed from 1)		H86 H88
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008201 heparin binding
GO:0046914 transition metal ion binding
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4jfn, PDBe:4jfn, PDBj:4jfn
PDBsum4jfn
PubMed25122912
UniProtP05067|A4_HUMAN Amyloid-beta precursor protein (Gene Name=APP)

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