Structure of PDB 4jej Chain A Binding Site BS01

Receptor Information
>4jej Chain A (length=241) Species: 376686 (Flavobacterium johnsoniae UW101) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KILTTIHQQILEAKKNGQKLLAILLDPDKIVWENLDHLLLKINQSPATHI
FVGGSIVESTIIEDLIAQLKQKTRLPVVIFPGDPSQISPKADAILFLSLL
SGRNPDYLIEYQVQAAPILKKTNLEVISTGYILIESGNETAVARVSKTEP
LNRENFDLALATAQAGEMLGSKLIYLEAGSGAKKPVPLEMISVISQNVEI
PIIVGGGIVDLHGIKKAYNAGADLVVIGTAFENDSHFFDSL
Ligand information
Ligand ID1GP
InChIInChI=1S/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m0/s1
InChIKeyAWUCVROLDVIAJX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(COP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H](COP(=O)(O)O)O)O
ACDLabs 10.04O=P(O)(O)OCC(O)CO
CACTVS 3.341OC[CH](O)CO[P](O)(O)=O
CACTVS 3.341OC[C@H](O)CO[P](O)(O)=O
FormulaC3 H9 O6 P
NameSN-GLYCEROL-1-PHOSPHATE
ChEMBL
DrugBank
ZINCZINC000003830895
PDB chain4jej Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4jej A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Resolution1.52 Å
Binding residue
(original residue number in PDB)		L27 Y178 E180 S183 G184 G208 G209 G231 T232
Binding residue
(residue number reindexed from 1)		L24 Y175 E177 S180 G181 G205 G206 G228 T229
Annotation score5
Enzymatic activity
Enzyme Commision number 2.5.1.41: phosphoglycerol geranylgeranyltransferase.
Gene Ontology
Molecular Function
GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0000287 magnesium ion binding
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0047294 phosphoglycerol geranylgeranyltransferase activity
Biological Process
GO:0006650 glycerophospholipid metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jej, PDBe:4jej, PDBj:4jej
PDBsum4jej
PubMed24684232
UniProtA5FJK8|GGGPS_FLAJ1 Geranylgeranylglyceryl phosphate synthase (Gene Name=Fjoh_1584)

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