Structure of PDB 4jdk Chain A Binding Site BS01

Receptor Information
>4jdk Chain A (length=290) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAV
KKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLE
GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLT
HDGRVKLSDFGVCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIW
SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL
DRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4jdk Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		S331 Q357 Q358 R359 T404 D440 D444 L475 G477 T478 P479 Y480 W481 L521 M524
Binding residue
(residue number reindexed from 1)		S32 Q58 Q59 R60 T105 D141 D145 L176 G178 T179 P180 Y181 W182 L222 M225
Enzymatic activity
Catalytic site (original residue number in PDB) D440 K442 D444 S445 D458 K467 T478
Catalytic site (residue number reindexed from 1) D141 K143 D145 S146 D159 K168 T179
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4jdk, PDBe:4jdk, PDBj:4jdk
PDBsum4jdk
PubMed24374310
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4)

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