Structure of PDB 4j9r Chain A Binding Site BS01

Receptor Information
>4j9r Chain A (length=423) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSY
EARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQ
GEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4j9r Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 S62 K86 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		Q36 Y37 W40 S60 K84 P310 K311 T312 G314 C315 S316 K317 N318 P320 R345
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4j9r, PDBe:4j9r, PDBj:4j9r
PDBsum4j9r
PubMed23630267
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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