Structure of PDB 4j3n Chain A Binding Site BS01

Receptor Information
>4j3n Chain A (length=666) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRG
KILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMI
MTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITAKEYFADMERHRI
LFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLKHLTYN
DFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQ
LAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHG
GKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIP
MVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFK
GTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNG
TDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLT
CNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAEST
KLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEG
PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLA
AFVEELDKVESQERED
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4j3n On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E477 G504 K505 D561 R729 K739 Y773 H775 G776 T783 N786 I872 R945 W947
Binding residue
(residue number reindexed from 1)		E23 G50 K51 D107 R217 K227 Y261 H263 G264 T271 N274 I360 R433 W435
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4j3n, PDBe:4j3n, PDBj:4j3n
PDBsum4j3n
PubMed24038465
UniProtQ02880|TOP2B_HUMAN DNA topoisomerase 2-beta (Gene Name=TOP2B)

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