Structure of PDB 4iyo Chain A Binding Site BS01

Receptor Information
>4iyo Chain A (length=381) Species: 291331 (Xanthomonas oryzae pv. oryzae KACC 10331) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHN
PTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYG
GTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPML
KLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLN
GHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPL
RMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIV
SIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARR
EQLGISDALVRLSVGIEDLGDLRGDLERALV
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain4iyo Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4iyo PLP undergoes conformational changes during the course of an enzymatic reaction.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		Y112 R117 E338
Binding residue
(residue number reindexed from 1)		Y99 R104 E325
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) R60 Y112 D185 K210
Catalytic site (residue number reindexed from 1) R47 Y99 D172 K197
Enzyme Commision number 4.4.1.1: cystathionine gamma-lyase.
Gene Ontology
Molecular Function
GO:0003962 cystathionine gamma-synthase activity
GO:0016846 carbon-sulfur lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iyo, PDBe:4iyo, PDBj:4iyo
PDBsum4iyo
PubMed24531493
UniProtQ5H4T8

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