Structure of PDB 4ixn Chain A Binding Site BS01

Receptor Information

>4ixn Chain A (length=318) Species: 83333 (Escherichia coli K-12)

MNPIAVTLLTGFLGAGKTTLLRHILNEQHGYKIAVIANEFGEVSVDDQLI
GDRATQIKTLTNGCIAASRSNELEDALLDLLDNLDKGNIQFDRLVIECTG
MADPGPIIQTFFSHEVLCQRYLLDGVIALVDAVHADEQMNQFTIAQSQVG
YADRILLTKTDVAGEAEKLHERLARINARAPVYTVTHGDIDLGLLFNTNG
FMLEENVVSTKPRFHFIADKQNDISSIVVELDYPVDISEVSRVMENLLLE
SADKLLRYKGMLWIDGEPNRLLFQGVQRLYSADWDRPWGDEKPHSTMVFI
GIQLPEEEIRAAFAGLRK

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4ixn Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4ixn Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases.
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): E74 H114
• Binding residue (residue number reindexed from 1): E74 H114
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0046914 transition metal ion binding

Biological Process

• GO:0006974 DNA damage response

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4ixn, PDBe:4ixn, PDBj:4ixn
• PDBsum: 4ixn
• PubMed: 24449932
• UniProt: P24203|YJIA_ECOLI Zinc chaperone YjiA (Gene Name=yjiA)