Structure of PDB 4iv4 Chain A Binding Site BS01
Receptor Information
>4iv4 Chain A (length=229) Species:
9606
(Homo sapiens) [
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SLALSLTADQMVSALLDAEPPILYSTRPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMS
NKGMEHLYSMKCKNVPLSDLLLEMLDAHR
Ligand information
>4iv4 Chain C (length=10) Species:
9606
(Homo sapiens) [
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HKILHRLLQD
Receptor-Ligand Complex Structure
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PDB
4iv4
Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
I358 K362 Q375 V376 L379 E380 D538 L539 E542
Binding residue
(residue number reindexed from 1)
I50 K54 Q67 V68 L71 E72 D219 L220 E223
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:4iv4
,
PDBe:4iv4
,
PDBj:4iv4
PDBsum
4iv4
PubMed
23524984
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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