Structure of PDB 4iu8 Chain A Binding Site BS01

Receptor Information
>4iu8 Chain A (length=422) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLRDWKPENPAFWENKGKHIARRNLWISVSCLLLAFCVWMLFSAVTVNLN
KIGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILI
IPCVWLGIAVQNPNTPFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQ
GSALGINGGLGNLGVSVMQLVAPLVIFVPVFAFLGVNGVPQADGSVMSLA
NAAWIWVPLLAIATIAAWSGMNDIALWLLSLLYLATFGSFIGFSAGFAML
AKTQFPDVNILRLAFFGPFIGAIARSVGGAISDKFGGVRVTLINFIFMAI
FSALLFLTLPGTGSGNFIAFYAVFMGLFLTAGLGSGSTFQMIAVIFRQIT
IYRVKMKGQAHKEAVTETAAALGFISAIGAVGGFFIPQAFGMSLNMTGSP
VGAMKVFLIFYIVCVLLTWLVY
Ligand information
Ligand IDNO3
InChIInChI=1S/NO3/c2-1(3)4/q-1
InChIKeyNHNBFGGVMKEFGY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-][N+]([O-])=O
OpenEye OEToolkits 1.5.0[N+](=O)([O-])[O-]
FormulaN O3
NameNITRATE ION
ChEMBLCHEMBL186200
DrugBankDB14049
ZINC
PDB chain4iu8 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4iu8 Structure and mechanism of a nitrate transporter.
Resolution3.11 Å
Binding residue
(original residue number in PDB)		R87 F145 N173 F265 R303
Binding residue
(residue number reindexed from 1)		R76 F134 N162 F237 R275
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015112 nitrate transmembrane transporter activity
GO:0015113 nitrite transmembrane transporter activity
GO:0015514 nitrite efflux transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0015706 nitrate transmembrane transport
GO:0015707 nitrite transport
GO:0042128 nitrate assimilation
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iu8, PDBe:4iu8, PDBj:4iu8
PDBsum4iu8
PubMed23523348
UniProtP37758|NARU_ECOLI Nitrate/nitrite transporter NarU (Gene Name=narU)

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