Structure of PDB 4if6 Chain A Binding Site BS01

Receptor Information
>4if6 Chain A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYAR
LAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIAL
SDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEA
VRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDE
VDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDC
DVIINELCHRLGGEYAKLCCNPVKLSEI
Ligand information
>4if6 Chain B (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GPHMGSQYLFLPPNRYIFHGAEVYSD
Receptor-Ligand Complex Structure
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PDB4if6 Structure of a nucleoporin complex
Resolution2.25 Å
Binding residue
(original residue number in PDB)		K236 N241 T242 I243 R466 P468 D475 E477 L479 G480 D481 I485
Binding residue
(residue number reindexed from 1)		K4 N9 T10 I11 R234 P236 D243 E245 L247 G248 D249 I253
Enzymatic activity
Catalytic site (original residue number in PDB) P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1) P39 D40 F41 R42 N114 D116 H131
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4if6, PDBe:4if6, PDBj:4if6
PDBsum4if6
PubMed
UniProtQ96EB6|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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