Structure of PDB 4icq Chain A Binding Site BS01

Receptor Information
>4icq Chain A (length=413) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVLPNFKENLEKYAKLLVANGINVQPGHTLALSIDVEQRELAHLIVKEAY
ALGAHEVIVQWTDDVINREKFLHAPMERLDNVPEYKIAEMNYLLENKASR
LGVRSSDPGALNGVDADKLSASAKAMGLAMKPMRIATQSNKVSWTVAAAA
GLEWAKKVFPNAASDEEAVDFLWDQIFKTCRVYEADPVKAWEEHAAILKS
KADMLNKEQFSALHYTAPGTDLTLGLPKNHVWESAGAVNAQGEEFLPNMP
TEEVFTAPDFRRADGYVTSTKPLSYNGNIIEGIKVTFKDGQIVDITAEKG
DQVMKDLVFENAGARALGECALVPDPSPISQSGITFFNTLFDENASNHLA
IGAAYATSVVDGAEMSEEELEAAGLNRSDVHVDFMIGSNQMDIDGIREDG
TRVPLFRNGNWAN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4icq Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4icq Structure-based elucidation of the regulatory mechanism for aminopeptidase activity.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		E319 Y355 H381 D383
Binding residue
(residue number reindexed from 1)		E319 Y355 H381 D383
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.-
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4icq, PDBe:4icq, PDBj:4icq
PDBsum4icq
PubMed23999297
UniProtA0A0H2UN95

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