Structure of PDB 4i9q Chain A Binding Site BS01

Receptor Information
>4i9q Chain A (length=846) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVIENMYGSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNV
GKLKYDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYY
AKIQIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPI
PNRYKYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERP
SDVYSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGQRTE
VAGMTAQINRKLLINSLAGALGNVWFRYYDLRNATAITTFGQMALQWIER
KVNEYLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVD
FLDKFARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIG
GFWTGKKRYALNVWAMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECI
RRMLQEGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGP
KCPFHIRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWP
SGTEITDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKA
Ligand information
Receptor-Ligand Complex Structure
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PDB4i9q A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E219 I253 E254 F359 I362 Y391 P392 G393 A394 S565 G568 N572 K705 R707 N786 K800 F803 K874 K878
Binding residue
(residue number reindexed from 1)		E219 I253 E254 F359 I362 Y391 P392 G393 A394 S516 G519 N523 K656 R658 N737 K751 F754 K825 K829
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4i9q, PDBe:4i9q, PDBj:4i9q
PDBsum4i9q
PubMed24116139
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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