Structure of PDB 4i7d Chain A Binding Site BS01

Receptor Information
>4i7d Chain A (length=187) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGS
LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFM
LVLEKQEQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHE
GIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
Ligand information
>4i7d Chain B (length=13) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KLRPVAMVRPKVR
Receptor-Ligand Complex Structure
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PDB4i7d Structure-based design of covalent siah inhibitors.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C130 L158 D162 I163 V164 F165 L166 T168 V176 D177 W178 M180 E194 N276 V277 T278
Binding residue
(residue number reindexed from 1)		C40 L68 D72 I73 V74 F75 L76 T78 V86 D87 W88 M90 E104 N181 V182 T183
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4i7d, PDBe:4i7d, PDBj:4i7d
PDBsum4i7d
PubMed23891150
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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