Structure of PDB 4i7c Chain A Binding Site BS01

Receptor Information
>4i7c Chain A (length=188) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGS
LDAVMPHLMHQHKSICTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFM
LVLEKQEKQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIH
EGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
Ligand information
>4i7c Chain B (length=13) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KLRPVAMVRPWVR
Receptor-Ligand Complex Structure
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PDB4i7c Structure-based design of covalent siah inhibitors.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S154 C156 L158 D162 I163 V164 F165 L166 T168 A175 V176 D177 W178 V179 M180 E194 N276
Binding residue
(residue number reindexed from 1)		S64 C66 L68 D72 I73 V74 F75 L76 T78 A85 V86 D87 W88 V89 M90 E104 N182
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4i7c, PDBe:4i7c, PDBj:4i7c
PDBsum4i7c
PubMed23891150
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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