Structure of PDB 4i2z Chain A Binding Site BS01

Receptor Information
>4i2z Chain A (length=899) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQTAEEIRDEGNAAVKDQDYIKADELYTEALQLTTDEDKALRPVLYRNRA
MARLKRDDFEGAQSDCTKALEFDGADVKALFRRSLAREQLGNVGPAFQDA
KEALRLSPNDKGIVEVLQRLVKANNDKIKQTTSLANKVTDMEKLAFRGEA
KDTEQKMTALNNLLVLCRESESGATGVWNQGALVPFVLNLINDASENEEV
TVTAIRILDETIKNSVRCMKFLAMHDPDGPKSVRFVCRLMCKKSTKDFVD
ATGILVQRVFNAMAKMDRQKEMKPDPEVAEANKIWIIRVLLELQEMLQDP
KVGAVQRETCIDLFLKNLMHMDGGIPRGWSWKFVEERGLLALLDVASQIP
ELCEYPVSAETRQHVAICLQRLEEDMVFDTKRTIFKEKVDMFFNALISRC
TNDDEGHKYRIKLSCFLITMLQGPVDIGINLITNDQLTPIMLEMAASQDH
LMQGIAAELIVATVSKHERAINMLKVGIPVLRALYDSEDPTVKVRALVGL
CKIVISLAKTCKKFLLETEKYSVDIRRYACEGLSYLSLDADVKEWIVDDS
LLLKALVLLAKKAGALCVYTLATIYANLSNAFEKPKFAKHHVPETHPKDT
EEYVEKRVRALVEEGAVPACVAVSKTESKNALELIARSLLAFAEYEDLRG
RIIAEGGTVLCLRLTKEASGEGKIKAGHAIAKLGAKADPMISFPGQRAYE
VVKPLCDLLHPDVEGKANYDSLLTLTNLASVSDSIRGRILKEKAIPKIEE
FWFMTDHEHLRAAAAELLLNLLFFEKFYEETVAPGTDRLKLWVLYSAEVE
EERLSRASAAGFAILTEDENACARIMDEIKSWPEVFKDIAMHEDAETQRR
GLMGIANIMHSSNKLCSEIVSSEVFRVLVAVTKLGTINQERAGSTEQAK
Ligand information
Receptor-Ligand Complex Structure
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PDB4i2z The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R12 N16 R51 N52 M55 V81 K82 F85
Binding residue
(residue number reindexed from 1)		R8 N12 R47 N48 M51 V77 K78 F81
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0044183 protein folding chaperone
GO:0051879 Hsp90 protein binding
Biological Process
GO:0007517 muscle organ development
GO:0009792 embryo development ending in birth or egg hatching
GO:0018991 egg-laying behavior
GO:0030154 cell differentiation
GO:0040011 locomotion
GO:0045214 sarcomere organization
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0032154 cleavage furrow
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4i2z, PDBe:4i2z, PDBj:4i2z
PDBsum4i2z
PubMed23332754
UniProtG5EG62

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