Structure of PDB 4hzz Chain A Binding Site BS01

Receptor Information

>4hzz Chain A (length=387) Species: 489926 (Influenza A virus (A/swine/Missouri/2124514/2006(H2N3)))

RPFKSPLPLCPFRGFFPFHKDNAIRLGENKDVIVTREPYVSCDNDNCWSF
ALAQGALLGTKHSNGTIKDRTPYRSLIRFPIGTAPVLGNYKEICIAWSSS
SCFDGKEWMHVCMTGNDNDASAQIIYGGRMTDSIKSWRKDILRTQESECQ
CIDGTCVVAVTDGPAANSADYRVYWIREGKIIKYENVPKTKIQYLEECSC
YVDIDVYCICRDNWKGSNRPWMRINNETILETGYVCSKFHSDTPRPADPS
TMSCDSPSNVNGGPGVKGFGFKAGDDVWLGRTVSTSGRSGFEIIKVTEGW
INSPNHVKSITQTLVSNNDWSGYSGSFIVKAKDCFQPCFYVELIRGRPNK
NDDVSWTSNSIVTFCGLDNEPGSGNWPDGSNIGFMPK

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4hzz Chain A Residue 507

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4hzz Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
• Resolution: 1.601 Å
• Binding residue (original residue number in PDB): D293 G297 D324 G345
• Binding residue (residue number reindexed from 1): D212 G216 D242 G262
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D151 E277 R292 R371 Y406
• Catalytic site (residue number reindexed from 1): D69 E197 R211 R288 Y323
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:4hzz, PDBe:4hzz, PDBj:4hzz
• PDBsum: 4hzz
• PubMed: 23824808
• UniProt: A9YN63