Structure of PDB 4htv Chain A Binding Site BS01

Receptor Information
>4htv Chain A (length=427) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFS
Ligand information
>4htv Chain B (length=7) Species: 77856 (Beak and feather disease virus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YRRRRRY
Receptor-Ligand Complex Structure
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PDB4htv Mouse importin alpha: BFDV Cap NLS peptide complex
Resolution3.0 Å
Binding residue
(original residue number in PDB)		F138 W142 N146 S149 G150 T151 S152 T155 W184 N188 D192 W231 R238 W273
Binding residue
(residue number reindexed from 1)		F68 W72 N76 S79 G80 T81 S82 T85 W114 N118 D122 W161 R168 W203
Enzymatic activity
Catalytic site (original residue number in PDB) T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1) T81 A93 N291 R296 Q297
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4htv, PDBe:4htv, PDBj:4htv
PDBsum4htv
PubMed
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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