Structure of PDB 4hsu Chain A Binding Site BS01

Receptor Information
>4hsu Chain A (length=737) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSRKCEKAGCTATCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDH
YYRSHKDGYDKYTTWKKIWTSNGKTEPSPKAFMADQQLPYWVQCTKPECR
KWRQLTKEIQLTPQIAKTYRCGMKSDHCSLPEDLRVLEVSNHWWYSMLIL
PPLLKDSVAAPLLSAYYPDCVGMSPSCTGMNRYFQPFYQPNECGKALCVR
PDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPHI
IVRGLVRIRCVQEVERILYFMTRKGLINTGVLSVGADQYLLPKDYHNKSV
IIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRG
AQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTIDKRMDF
HFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQV
LQFHLSNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEK
LAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKG
AIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVP
PSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMA
TLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAED
IQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4hsu Structural insight into substrate recognition by histone demethylase LSD2/KDM1b.
Resolution1.988 Å
Binding residue
(original residue number in PDB)		Y273 G279 L282 C283 V284 E290 D292 K359 L361 A566 N798 H800 F801 R814
Binding residue
(residue number reindexed from 1)		Y188 G194 L197 C198 V199 E205 D207 K274 L276 A481 N713 H715 F716 R729
Enzymatic activity
Catalytic site (original residue number in PDB) N440
Catalytic site (residue number reindexed from 1) N355
Enzyme Commision number 1.14.99.66: [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0032452 histone demethylase activity
GO:0032453 histone H3K4 demethylase activity
GO:0042393 histone binding
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
GO:0140682 FAD-dependent H3K4me/H3K4me3 demethylase activity
Biological Process
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0044726 epigenetic programing of female pronucleus
GO:0071514 genomic imprinting
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hsu, PDBe:4hsu, PDBj:4hsu
PDBsum4hsu
PubMed23357850
UniProtQ8NB78|KDM1B_HUMAN Lysine-specific histone demethylase 2 (Gene Name=KDM1B)

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