Structure of PDB 4hkq Chain A Binding Site BS01

Receptor Information
>4hkq Chain A (length=441) Species: 373193 (Xenotropic MuLV-related virus VP62) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLGIKPH
IQRLLDQGILVPCQSPWNTPLLPVKKDYRPVQDLREVNKRVEDIHPTVPN
PYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWRDQLTWTRL
PQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAATSEQDCQR
GTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLLKEGQRWLTEARKETV
MGQPTPKTPRQLREFLGTAGFCRLWIPGFAEMAAPLYPLTKTLFNWGPDQ
QKAYQEIKQALLTAPALGLPDLTKPFELFVDEKQGYAKGVLTQKLGPWRR
PVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDAGKLTMGQPLVILAPHAV
EALVKQPPARMTHYQAMLLDTDRVQFGPVVALNPATLLPLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4hkq Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
Resolution3.04 Å
Binding residue
(original residue number in PDB)		Y64 L99 V112 D114 R116 V129 P132 Y133 G191 K193 P196 R311 Y325 K397 K398
Binding residue
(residue number reindexed from 1)		Y37 L72 V81 D83 R85 V98 P101 Y102 G153 K155 P158 R273 Y287 K357 K358
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:4hkq, PDBe:4hkq, PDBj:4hkq
PDBsum4hkq
PubMed23382176
UniProtA1Z651|POL_XMRV6 Gag-Pol polyprotein (Gene Name=gag-pol)

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