Structure of PDB 4hht Chain A Binding Site BS01

Receptor Information
>4hht Chain A (length=220) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIDELYKKEFGIVAGVDEASRGCLAGPVVAAAVVLEKEIEGINDSRLLDE
IMEKAAVGIGIASPEEIDLYNIFNATKLAMNRALENLSVKPSFVLVDGKG
IELSVPGTCLVKGDQKSKLIGAASIVAKVFRDRLMSEFHRMYPQFSFHKH
KGYATKEHLNEIRKNGVLPIHRLSFEPVLELLTDDLLREFFEKGLISENR
FERILNLLGARKSVVFRKER
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4hht RNase H2 roles in genome integrity revealed by unlinking its activities.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		G23 N81 I82 F83 F185 E186 P187
Binding residue
(residue number reindexed from 1)		G22 N71 I72 F73 F175 E176 P177
Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006298 mismatch repair
GO:0006401 RNA catabolic process
GO:0043137 DNA replication, removal of RNA primer
Cellular Component
GO:0005737 cytoplasm
GO:0032299 ribonuclease H2 complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4hht, PDBe:4hht, PDBj:4hht
PDBsum4hht
PubMed23355612
UniProtQ9X017|RNH2_THEMA Ribonuclease HII (Gene Name=rnhB)

[Back to BioLiP]