Structure of PDB 4hf1 Chain A Binding Site BS01

Receptor Information
>4hf1 Chain A (length=129) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLR
KNGLVSSVRGPGGGYLLGKDASSIAVGEVISAVDESVDALTHALWRDLSD
RLTGFLNNITLGELVNNQEVLDVSGRQHT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4hf1 Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity.
Resolution2.222 Å
Binding residue
(original residue number in PDB)		R2 S5 K6 Y9 S38 S40 Y41 Q44 R59 G60 P61
Binding residue
(residue number reindexed from 1)		R2 S5 K6 Y9 S38 S40 Y41 Q44 R59 G60 P61
Binding affinityPDBbind-CN: Kd=17nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005506 iron ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hf1, PDBe:4hf1, PDBj:4hf1
PDBsum4hf1
PubMed23644595
UniProtP0AGK8|ISCR_ECOLI HTH-type transcriptional regulator IscR (Gene Name=iscR)

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