Structure of PDB 4hda Chain A Binding Site BS01

Receptor Information
>4hda Chain A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQD
LATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRR
VVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPAL
SGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEE
VDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNR
FRFHFQGPCGTTLPEAL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4hda A molecular mechanism for direct sirtuin activation by resveratrol.
Resolution2.601 Å
Binding residue
(original residue number in PDB)		E225 N226
Binding residue
(residue number reindexed from 1)		E191 N192
Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) P34 T35 F36 R37 N107 D109 H124
Enzyme Commision number 2.3.1.-
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4hda, PDBe:4hda, PDBj:4hda
PDBsum4hda
PubMed23185430
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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