Structure of PDB 4hd6 Chain A Binding Site BS01

Receptor Information
>4hd6 Chain A (length=287) Species: 1404 (Priestia megaterium) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYRVRKNVLHLTDTEKRDFVRTVLILKEKGIYDRYIAWHGAAGKFHTPPG
SDRNAAHMSSAFLPWHREYLLRFERDLQSINPEVTLPYWEWETDAQMQDP
SQSQIWSADFMGGNGNPIKDFIVDTGPFAAGRWTTIDEQGNPSGGLKRNF
GATKEAPTLPTRDDVLNALKITQYDTPPWDMTSQNSFRNQLEGFINGPQL
HNRVHRWVGGQMGVFPTAPNDPVFFLHHANVDRIWAVWQIIHRNQNYQPM
KNGPFGQNFRDPMYPWNTTPEDVMNHRKLGYVYDIEL
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain4hd6 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4hd6 Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H42 H60 H69
Binding residue
(residue number reindexed from 1)		H39 H57 H66
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y35 H60 H69 H204 H208 F218 H231
Catalytic site (residue number reindexed from 1) Y32 H57 H66 H201 H205 F215 H228
Enzyme Commision number 1.14.18.1: tyrosinase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4hd6, PDBe:4hd6, PDBj:4hd6
PDBsum4hd6
PubMed23305929
UniProtB2ZB02

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