Structure of PDB 4hab Chain A Binding Site BS01
Receptor Information
>4hab Chain A (length=223) Species:
9606
(Homo sapiens) [
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DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSA
IILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEY
GCCKELASRLRYARTMVDKLLSS
Ligand information
>4hab Chain D (length=6) Species:
32630
(synthetic construct) [
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PLHSTM
Receptor-Ligand Complex Structure
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PDB
4hab
Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
Resolution
2.65 Å
Binding residue
(original residue number in PDB)
K413 W414 D416 Y485 H489 L490 L491 R516 F535 H538 K540
Binding residue
(residue number reindexed from 1)
K43 W44 D46 Y115 H119 L120 L121 R146 F165 H168 K170
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4hab
,
PDBe:4hab
,
PDBj:4hab
PDBsum
4hab
PubMed
23498919
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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