Structure of PDB 4h5j Chain A Binding Site BS01

Receptor Information
>4h5j Chain A (length=343) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFVTASYNVGYPAYGAKFLNNDTLLVAGGGGEGNNGIPNKLTVLRVDPTK
DTEKEQFHILSEFALEDNDDSPTAIDASKGIILVGCNENSTKITQGKGNK
HLRKFKYDKVNDQLEFLTSVDFDASTNADDYTKLVYISREGTVAAIASSK
VPAIMRIIDPSDLTEKFEIETRGEVKDLHFSTDGKVVAYITGSSLEVIST
VTGSCIARKTDFDKNWSLSKINFIADDTVLIAASLKKGKGIVLTKISIKS
GNTSVLRSKQVTNRFKGITSMDVDMKGELAVLASNDNSIALVKLKDLSMS
KIFKQAHSFAITEVTISPDSTYVASVSAANTIHIIKLPLNYAN
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain4h5j Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4h5j The structure of sec12 implicates potassium ion coordination in sar1 activation.
Resolution2.601 Å
Binding residue
(original residue number in PDB)		G32 E33 G34 N35 N36 I38 N40 D68
Binding residue
(residue number reindexed from 1)		G31 E32 G33 N34 N35 I37 N39 D67
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity

View graph for
Molecular Function
External links
PDB RCSB:4h5j, PDBe:4h5j, PDBj:4h5j
PDBsum4h5j
PubMed23109340
UniProtP11655|SEC12_YEAST Guanine nucleotide-exchange factor SEC12 (Gene Name=SEC12)

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