Structure of PDB 4h36 Chain A Binding Site BS01

Receptor Information
>4h36 Chain A (length=353) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKK
LSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYL
VMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN
IVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENV
DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV
RNYVENRPKYAGLTFPKLFPDSLFPEHNKLKASQARDLLSKMLVIDPAKR
ISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKE
VMN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4h36 Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		A151 M159 E164 R165 Y168 S199 D200 C201 W362
Binding residue
(residue number reindexed from 1)		A107 M115 E120 R121 Y124 S155 D156 C157 W315
Enzymatic activity
Catalytic site (original residue number in PDB) D189 K191 N194 D207 T226
Catalytic site (residue number reindexed from 1) D145 K147 N150 D163 T182
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4h36, PDBe:4h36, PDBj:4h36
PDBsum4h36
PubMed23142346
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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