Structure of PDB 4gz2 Chain A Binding Site BS01

Receptor Information
>4gz2 Chain A (length=248) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYL
KKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCV
NVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAG
DTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAY
KHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gz2 Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		D132 L134 D135 E162 I164 T240 R241 R276 W307 L315 I317 Y321 H323
Binding residue
(residue number reindexed from 1)		D11 L13 D14 E41 I43 T119 R120 R155 W186 L194 I196 Y200 H202
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4gz2, PDBe:4gz2, PDBj:4gz2
PDBsum4gz2
PubMed23104055
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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