Structure of PDB 4gyy Chain A Binding Site BS01

Receptor Information

>4gyy Chain A (length=693) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQ
QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ
INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL
QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAI
AERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHL
MQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGK
AADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALF
MDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDF
HIYDNRIVLNGIDLKAFLDSLPDVKIVNMPVIPMNTIAEAVIEMINRGQI
QITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYC
NFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGL
PQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVT
MPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRG
KVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK

Ligand information

>4gyy Chain B (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YPGGSTPVSSANMM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4gyy Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Resolution	1.85 Å
Binding residue (original residue number in PDB)	D431 S494 H496 H517 N557 H558 P559 Y632 T633 K634 Q839 V895 A896 P897
Binding residue (residue number reindexed from 1)	D118 S181 H183 H204 N244 H245 P246 Y319 T320 K321 Q504 V560 A561 P562

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:4gyy, PDBe:4gyy, PDBj:4gyy
PDBsum	4gyy
PubMed	23103939
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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