Structure of PDB 4gyw Chain A Binding Site BS01

Receptor Information

>4gyw Chain A (length=695) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQ
QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ
INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL
QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAI
AERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHL
MQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGK
AADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALF
MDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDF
KHIYDNRIVLNGIDLKAFLDSLPDVKIVKNMPVIPMNTIAEAVIEMINRG
QIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIV
YCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM
GLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPM
VTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKV
RGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK

Ligand information

>4gyw Chain B (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YPGGSTPVSSANMM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4gyw Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Resolution	1.7 Å
Binding residue (original residue number in PDB)	H496 H517 N557 H558 Y632 T633 K634 Q839 V895 P897
Binding residue (residue number reindexed from 1)	H183 H204 N244 H245 Y319 T320 K321 Q506 V562 P564

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:4gyw, PDBe:4gyw, PDBj:4gyw
PDBsum	4gyw
PubMed	23103939
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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