Structure of PDB 4gx2 Chain A Binding Site BS01

Receptor Information

>4gx2 Chain A (length=375) Species: 243231 (Geobacter sulfurreducens PCA)

QNLKVLLLYCAFLLVMLLAYASIFRYLMWHLEGRAYSFMAGIYWTITVMT
TLGFGDITFESDAGYLFASIVTVSGVIFLDIILPFGFVSMFLAPWIERRL
RYHPTIELPDDTRGHILIFGIDPITRTLIRKLESRNHLFVVVTDNYDQAL
HLEEQEGFKVVYGSPTDAHVLAGLRVAAARSIIANLSDPDNANLCLTVRS
LCQTPIIAVVKEPVHGELLRLAGANQVVPLTRILGRYLGIRATTEDELIF
IIGHGRIGCAAAAFLDRKPVPFILIDRQESPVCNDHVVVYGDATVGQTLR
QAGIDRASGIIVTTNDDSTNIFLTLACRHLHSHIRIVARANGEENVDQLY
AAGADFVVSNASVGANILGNLLEHK

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4gx2 Chain A Residue 606

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4gx2 Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): H359 C364 C388 H391
• Binding residue (residue number reindexed from 1): H254 C259 C283 H286
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003674 molecular_function
• GO:0008324 monoatomic cation transmembrane transporter activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006813 potassium ion transport
• GO:0008150 biological_process
• GO:0098655 monoatomic cation transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4gx2, PDBe:4gx2, PDBj:4gx2
• PDBsum: 4gx2
• PubMed: 23240087
• UniProt: Q74FS9