Structure of PDB 4grv Chain A Binding Site BS01

Receptor Information

>4grv Chain A (length=454) Species: 10116,10665

NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKSLQSTVHYH
LGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYA
TALNVASLSVARYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPML
FTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISI
LNTVIANKLTVMVNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPS
LNAAKSELDKRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSL
DAVRRAALINMVFQMGETGVAGFTNSLRMLNNKRWDEAAVNLAKSRWYNQ
TPNRAKRVITTFRTGTWDAYGSGSVQALRHGVLVARAVVIAFVVCWLPYH
VRRLMFCYISDEQWTTFLFDFYHYFYMLTNALAYASSAINPILYNLVSAN
FRQV

Ligand information

>4grv Chain B (length=6) Species: 10116 (Rattus norvegicus)

RRPYIL

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4grv Structure of the agonist-bound neurotensin receptor.
• Resolution: 2.802 Å
• Binding residue (original residue number in PDB): L55 F128 H132 Y146 R213 V224 T226 R327 R328 F331 S335 W339 F344 Y347 Y351
• Binding residue (residue number reindexed from 1): L4 F73 H77 Y91 R158 V169 T171 R402 R403 F406 S410 W414 F419 Y422 Y426

Enzymatic activity

• Catalytic site (original residue number in PDB): E1011 D1020
• Catalytic site (residue number reindexed from 1): E223 D232
• Enzyme Commision number:
  3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004930 G protein-coupled receptor activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0009253 peptidoglycan catabolic process
• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0044659 viral release from host cell by cytolysis

Cellular Component

• GO:0016020 membrane
• GO:0030430 host cell cytoplasm

External links

• PDB: RCSB:4grv, PDBe:4grv, PDBj:4grv
• PDBsum: 4grv
• PubMed: 23051748
• UniProt: P00720|ENLYS_BPT4 Endolysin (Gene Name=E);
  P20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)