Structure of PDB 4gq6 Chain A Binding Site BS01

Receptor Information
>4gq6 Chain A (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSVPVLTFQSEKMKGMKELLVATKIN
SSAIKLQLTAQSQVQMK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gq6 Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		D136 R137 A138 D153 S155 D180 H181 F238 C241 L249 M278 Y319 Y323 E359 E363
Binding residue
(residue number reindexed from 1)		D115 R116 A117 D132 S134 D159 H160 F217 C220 L228 M257 Y298 Y302 E338 E342
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4gq6, PDBe:4gq6, PDBj:4gq6
PDBsum4gq6
PubMed22936661
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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