Structure of PDB 4gpu Chain A Binding Site BS01

Receptor Information
>4gpu Chain A (length=331) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSLVLSCKKFPHVSVNYVVDKTPKLLTDCKEVHNCSYIINDATLLWNEAS
RKPRLRPEVCTYIKDSKWENKAVKDSFIGIDLTKGYDDNSLVILKEAYQR
YEKTLNPEKTTFVSLRHHIIDIIMCPFLDEPLSLLMTVQPDKNILISVDN
KKICYTGFALEDLLIEHELYYSIVHGSLNDEIDLLIQAEMDSINTLTDTY
TEIKSSVHFKLGNTYHRRKLLRMWIQTNLLPKSDLLIGFRNSYSNELEQL
KAYKIQDIYHKINNSSIVGKPGKFYKFNPNVANDWFQHIFQVLKQNLLLL
SQESTSTTFKVQIDTNLTLSISPASQFVTAL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4gpu Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4gpu Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E223 D262 E273 I274
Binding residue
(residue number reindexed from 1)		E161 D191 E202 I203
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.13.-
3.6.1.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004527 exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0034353 mRNA 5'-diphosphatase activity
GO:0046872 metal ion binding
GO:0110152 RNA NAD+-cap (NAD+-forming) hydrolase activity
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0071028 nuclear mRNA surveillance
GO:0090304 nucleic acid metabolic process
GO:0110155 NAD-cap decapping
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gpu, PDBe:4gpu, PDBj:4gpu
PDBsum4gpu
PubMed22961381
UniProtQ6CPU0|DXO1_KLULA Decapping and exoribonuclease protein 1 (Gene Name=DXO1)

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