Structure of PDB 4gpr Chain A Binding Site BS01

Receptor Information
>4gpr Chain A (length=150) Species: 5759 (Entamoeba histolytica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAMAMRRIQKELREIQQDPPCNCSAGPVGDDIFHWTATITGPDDSPYQGG
LFFLDVHFPVDYPFKAPRVTFMTKVYHPNINKNGVICLDILKDQWSPALT
LSRVLLSISSLLTDPNPSDPLDPEVANVLRANKKQFEDTAREWTRMYARP
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain4gpr Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4gpr Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		H32 D53 H55
Binding residue
(residue number reindexed from 1)		H34 D55 H57
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) C85
Catalytic site (residue number reindexed from 1) C87
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0061631 ubiquitin conjugating enzyme activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:4gpr, PDBe:4gpr, PDBj:4gpr
PDBsum4gpr
PubMed23209297
UniProtC4M5T2

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