Structure of PDB 4gnf Chain A Binding Site BS01

Receptor Information
>4gnf Chain A (length=96) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQC
DECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gnf The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		E1321 D1322 Y1323 G1328 D1329 G1330 G1331 E1332 L1333 V1334 M1335 P1356 G1358
Binding residue
(residue number reindexed from 1)		E4 D5 Y6 G11 D12 G13 G14 E15 L16 V17 M18 P39 G41
Enzymatic activity
Enzyme Commision number 2.1.1.370: [histone H3]-lysine(4) N-dimethyltransferase.
2.1.1.371: [histone H3]-lysine(27) N-dimethyltransferase.
External links
PDB RCSB:4gnf, PDBe:4gnf, PDBj:4gnf
PDBsum4gnf
PubMed23269674
UniProtQ9BZ95|NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (Gene Name=NSD3)

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