Structure of PDB 4glx Chain A Binding Site BS01 |
| >4glx Chain A (length=573) Species: 83333 (Escherichia coli K-12)
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SIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPEL
ITPDSPTQRPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRTWCCE
LKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGEN
IPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPR
ITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESA
EEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAF
KFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADE
IERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGS
DVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLV
EKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLY
ALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNF
FAEESNRNVISELLAEGVHWPAP |
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| PDB | 4glx Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity. |
| Resolution | 1.9 Å |
Binding residue
(original residue number in PDB) | E29 R97 K194 F196 N201 G205 Q209 L210 R218 V303 A304 R308 Q330 G332 R333 T334 T338 V351 L352 V353 S354 N355 I384 P385 R487 M488 G489 S492 E519 G521 A523 T524 |
Binding residue
(residue number reindexed from 1) | E27 R91 K181 F183 N188 G192 Q196 L197 R205 V290 A291 R295 Q317 G319 R320 T321 T325 V338 L339 V340 S341 N342 I371 P372 R474 M475 G476 S479 E506 G508 A510 T511 |
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| Catalytic site (original residue number in PDB) |
Y225 T427 |
| Catalytic site (residue number reindexed from 1) |
Y212 T414 |
| Enzyme Commision number |
6.5.1.2: DNA ligase (NAD(+)). |
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