Structure of PDB 4gl2 Chain A Binding Site BS01

Receptor Information
>4gl2 Chain A (length=617) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQLRPYQMEVAQPALEGKNIIICLPTGCGKTRVAVYIAKDHLDKKKKASE
PGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSLKISFPEVVKSCDI
IISTAQILENSLLGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLK
NNRLKKVIPLPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTV
KENLDQLKNQIQEPCKKFAIADPFKEKLLEIMTRIQTYCQMSPMSDFGTQ
PYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQINDTIRMIDAYTHL
ETFYNEEKDKKFLDETDRFLMTLFFENNKMLKRLAENPEKLTKLRNTIME
QYTRTEESARGIIFTKTRQSAYALSQWITENEKFAAHHLIGAGHSSEFKP
MTQNEQKEVISKFRTNLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQ
ARGRARADESTYVLVAHSGSGVIERETVNDFREKMMYKAIHCVQNMKPEE
YAHKILELQMQSIMEKKMKTKPSLITFLCKNCSVLACSGEDIHVIEKMHH
VNMTPEFKELYIVRGEIICKCGQAWGTMMVHKLPCLKIRNFVVVFKNNST
KKQYKKWVELPITFPNL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gl2 Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5.
Resolution3.557 Å
Binding residue
(original residue number in PDB)		E451 A452 Q580 N812 R843 H927 M972 K983 W1003 V1004
Binding residue
(residue number reindexed from 1)		E134 A135 Q254 N444 R475 H549 M579 K587 W607 V608
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:4gl2, PDBe:4gl2, PDBj:4gl2
PDBsum4gl2
PubMed23273991
UniProtQ9BYX4|IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (Gene Name=IFIH1)

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