Structure of PDB 4gfv Chain A Binding Site BS01

Receptor Information
>4gfv Chain A (length=286) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPE
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQ
GPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTG
LFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPPDHM
LAMVEEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPPD
FSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gfv PTPN18-HER2 peptides
Resolution2.095 Å
Binding residue
(original residue number in PDB)		Y62 D64 V65 D197 R198 S229 S230 A231 G232 C233 G234 R235 Q276
Binding residue
(residue number reindexed from 1)		Y57 D59 V60 D192 R193 S222 S223 A224 G225 C226 G227 R228 Q269
Enzymatic activity
Catalytic site (original residue number in PDB) D197 S229 R235 T236 Q276
Catalytic site (residue number reindexed from 1) D192 S222 R228 T229 Q269
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gfv, PDBe:4gfv, PDBj:4gfv
PDBsum4gfv
PubMed
UniProtQ99952|PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (Gene Name=PTPN18)

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