Structure of PDB 4gfh Chain A Binding Site BS01

Receptor Information
>4gfh Chain A (length=1102) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTI
VPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPI
EIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEF
ILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRF
GMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLK
SLIPTILYERINNRWEVAFAVSDISFQQISFVNSIATTMGGTHVNYITDQ
IVKKISEILKKKKKKSVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTTR
VKDFGSRCEIPLEYINKIMKTDLATRMFEIADANESRITNYPKLEDANKA
GTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREAS
ADQILKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIK
GLIINFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYE
KWREEESHKFTWKQKYYTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYID
LAFSKKKADDRKEWLRQYEPGTVLDPTLKEIPISDFINKELILFSLADNI
RSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQ
SLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNK
LTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWST
YIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGR
IEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDD
NIKFIITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNS
VNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELT
VTNKPRNAIIQELENLGFPRFNKEGKPYYGSEELYGTYEYLLGMRIWSLT
KERYQKLLKQKQEKETELENLLKLSAKDIWNTDLKAFEVGYQEFLQRDAE
AR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gfh Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity.
Resolution4.408 Å
Binding residue
(original residue number in PDB)		D530 R690 K700 Y734 H736 S740 K775 E831 I833 W908
Binding residue
(residue number reindexed from 1)		D495 R651 K661 Y695 H697 S701 K736 E792 I794 W869
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gfh, PDBe:4gfh, PDBj:4gfh
PDBsum4gfh
PubMed23022727
UniProtP06786|TOP2_YEAST DNA topoisomerase 2 (Gene Name=TOP2)

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