Structure of PDB 4gez Chain A Binding Site BS01

Receptor Information
>4gez Chain A (length=365) Species: 1129346 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/164/2009(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YWRAKSQMCEVKGWVPTHRGFPWGPELPGDLILSRRAYVSCDLTSCFKFF
IAYGLSANQHLLNTSMEWEESLYKTPIGSASTLSTSEMILPGRSSSACFD
GLKWTVLVANGRDRNSFIMIKYGEEVTDTFSASRGGPLRLPNSECICIEG
SCFVIVSDGPNVNQSVHRIYELQNGTVQRWKQLNTTGINFEYSTCYTINN
LIKCTGTNLWNDAKRPLLRFTKELNYQIVEPCNGAPTDFPRGGLTTPSCK
MAQEKGEGGIQGFILDEKPAWTSKTKAESSQNGFVLEQIPNGIESEGTVS
LSYELFSNKRTGRSGFFQPKGDLISGCQRICFWLEIEDQTVGLGMIQELS
TFCGINSPVQNINWD
Ligand information
Ligand IDFUC
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1
InChIKeySHZGCJCMOBCMKK-SXUWKVJYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namealpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose
ChEMBLCHEMBL1232862
DrugBankDB04473
ZINCZINC000001532814
PDB chain4gez Chain M Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4gez Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		I264 I304
Binding residue
(residue number reindexed from 1)		I188 I228
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) W144 Y268 T283 Q357 R389
Catalytic site (residue number reindexed from 1) W68 Y192 T207 Q281 R313
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gez, PDBe:4gez, PDBj:4gez
PDBsum4gez
PubMed23012478
UniProtH6QM85

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